Valproate teratogenicity and epilepsy syndrome
نویسندگان
چکیده
منابع مشابه
Valproate teratogenicity and epilepsy syndrome.
Maternal valproate (VPA) use is associated with a significant risk for congenital malformations in the exposed fetus. Since VPA is commonly used in epilepsy syndromes with a presumed genetic cause (idiopathic epilepsies), it is possible that maternal genetic background contributes to this outcome. We reviewed responses to telephone questionnaires and medical records, when available, of enrollee...
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Sodium valproate has a simple chemical structure unlike other anticonvulsants. It has been given to 63 patients with various types of epilepsy whose attacks were frequent and of whom 40 had failed to respond to other anticonvulsants. Fits stopped completely in 27 patients (43%) and 14 (22%) showed a reduction ofattacks by more than 50%. The best results were in patients with absences (typical a...
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متن کاملFetal valproate syndrome.
There is an increased incidence of major and minor congenital abnormalities in infants born to epileptic mothers (6 to 7% compared with 2 to 3% in the general population).' Factors which may contribute to this include the occurrence of seizures leading to periods of hypoxia during pregnancy, an inherited predisposition to malformations owing to intrinsic maternal factors, and the teratogenic ef...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2008
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1167.2008.01696.x